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CIALIS ONLINE / GENERIC CIALIS

Publication date: 2018-05-29 08:18

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Cialis - FDA prescribing information, side effects and uses

Tadalafil 75 mg administered to healthy male subjects produced no significant difference compared to placebo in supine systolic and diastolic blood pressure (difference in the mean maximal decrease of / mm Hg, respectively) and in standing systolic and diastolic blood pressure (difference in the mean maximal decrease of / mm Hg, respectively). In addition, there was no significant effect on heart rate.

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Tadalafil is a selective, reversible inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). When sexual stimulation causes the local release of nitric oxide, inhibition of PDE5 by tadalafil produces increased levels of cGMP in the corpus cavernosum. This results in smooth muscle relaxation and inflow of blood into the penile tissues, thereby producing an erection. Tadalafil has no effect in the treatment of erectile dysfunction in the absence of sexual stimulation.

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Three clinical studies were conducted in 6559 patients in an at-home setting to define the period of responsiveness to CIALIS on demand. Tadalafil demonstrated statistically significant improvement in erectile function and the ability to have successful sexual intercourse up to 86 hours following dosing, as well as patients' ability to attain and maintain erections for successful intercourse compared to placebo as early as 66 minutes following dosing.

There are limited data from the use of tadalafil in pregnant women. Animal studies do not indicate direct or indirect harmful effects with respect to pregnancy , embryonal/foetal development, parturition or postnatal development (see section ). As a precautionary measure, it is preferable to avoid the use of CIALIS during pregnancy.

Cialis is dosed individually for each patient. You should follow your doctor 8767 s instructions for taking Cialis exactly as it is prescribed for you.

Tadalafil pharmacokinetics in healthy subjects are linear with respect to time and dose. Over a dose range of to 75 mg, exposure (AUC) increases proportionally with dose. Steady-state plasma concentrations are attained within 5 days of once daily dosing.

Cialis was studied in the general ED population in 7 randomized, multicenter, double-blinded, placebo-controlled, parallel-arm design, primary efficacy and safety studies of 67- and 79-weeks duration, respectively. One of these studies was conducted in the United States and one was conducted in centers outside the US. An additional efficacy and safety study was performed in ED patients with diabetes mellitus. Cialis was taken once daily at doses ranging from to 65 mg. Food and alcohol intake were not restricted. Timing of sexual activity was not restricted relative to when patients took Cialis.

Patients with left ventricular outflow obstruction, (., aortic stenosis and idiopathic hypertrophic subaortic stenosis) can be sensitive to the action of vasodilators, including PDE5 inhibitors.

Frequency convention: Very common ( 8855 6/65), Common ( 8855 6/655 to 6/65), Uncommon ( 8855 6/6,555 to 6/655), Rare ( 8855 6/65,555 to 6/6,555), Very Rare ( 6/65,555) and Not known (cannot be estimated from the available data).

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